Crosslinked chondroitin sulfate, composition containing same, and treatment agent for eye disease
AssigneeSeikagaku Corporation
InventorsSho Funayama, Risa Nodera, Takahiro Hatanaka
Life of this patent
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Abstract
Provided is a chondroitin sulfate derivative having a cross-linked structure through a group in a polyvalent amine. Also provided is a composition containing the chondroitin sulfate derivative. Also provided are an agent and method for the treatment of an eye disease, the agent and method having a therapeutic effect on a corneal epithelial disorder and/or dry eye.
Claims12
A method for the treatment of a corneal epithelial disorder and/or dry eye in a subject in need thereof, the method comprising administering a composition comprising a chondroitin sulfate derivative having a cross-linked structure through a cross-linker, the derivative being cross-linked between disaccharide units of chondroitin sulfate, and a pharmaceutically acceptable carrier to at least one eye of the subject,
- wherein the composition is in the form of an aqueous solution, and
- wherein the composition passes through a porous filter (pore size:
- 5.0 μm, diameter:
- 25 mm) at a passing rate of 80% or more at 25° C.
Dependencies are inferred from the claim text.