Polysaccharide particle mixture
AssigneeMedtronic, Inc.
InventorsJennifer G. Medina, James Britton Hissong, Matthew F. Myntti, Dana A. Oliver, Brian J. Vaccaro
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Abstract
Tissue and other body structures may be protected using a dry, free-flowing, sterilized mixture of chitosan particles and oxidized polysaccharide particles in sealed packaging. The mixture may assist in returning an injured, inflamed or surgically repaired surface to a normal state, e.g., through one or more healing mechanisms such as modulation of an inflammatory response, phagocytosis, mucosal remodeling, reciliation or other full or partial restoration of normal function.
Claims19
A composition comprising a dry, free-flowing, sterilized mixture of separate rehydratable particles comprising about 20 to about 95 wt. % of chitosan particles containing amino groups and about 80 to about 5 wt. % of oxidized polysaccharide particles containing aldehyde groups in sealed packaging, wherein the amino group functionality and molecular weight of the chitosan and the aldehyde group and molecular weight of the oxidized polysaccharide are such that the mixture of chitosan particles and separate oxidized polysaccharide particles are rehydratable in situ when removed from the sealed packaging and applied in a dry state to a surgical tissue site or wound moistened with bodily fluids such that the mixture of chitosan particles and separate oxidized polysaccharide particles will adhere to such tissue site or wound and will adhere to one another by inter-particle crosslinking reaction of amino groups on the chitosan particles with aldehyde groups on the polysaccharide particles, wherein the dry, free-flowing, sterilized mixture of chitosan and oxidized polysaccharide particles contains less than 10% wt. % water.
Dependencies are inferred from the claim text.