Composition of novel carbohydrate drug for treatment of human diseases
AssigneeGalectin Therapeutics, Inc.
InventorsEliezer Zomer, Peter G. Traber, Anatole A. Klyosov, Elena Chekhova
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Abstract
Aspects of the invention provide compositions for use in the treatment galectin-dependent diseases. In particular, compositions comprising a selectively depolymerized, branched galactoarabino-rhamnogalacturonate whose backbone is predominantly comprised of 1,4-linked galacturonic acid (GalA) moieties, with a lesser backbone composition of alternating 1,4-linked GalA and 1,2-linked rhamnose (Rha), which in-turn is linked to any number of side chains, including predominantly 1,4-b-D-galactose (Gal) and 1,5-a-L-arabinose (Ara) residues.
Claims17
A method comprising:
- a. obtaining a composition for parenteral or enteral administration, the composition comprising a complex carbohydrate backbone of 1,4-linked galacturonic acid (GalA) and 1,4-linked methyl galacturonate (MeGalA) residues with interspersed α-1,2 linked rhamnose within the carbohydrate backbone, the rhamnose residues carrying a primary branching of oligomers of 1,4-β-D-galactose residues, 1,5-α-L-arabinose residues, or combinations thereof,
- wherein the molar percent of the oligomers of 1,4-β-D-galactose residues and 1,5-α-L-arabinose residues is greater than 10% of the total carbohydrate molar content,
- wherein the compound has a degree of methoxylation ranging from 33% to 66%, and
- wherein the 1,4-β-D-galactose and 1,5-α-L-arabinose residues are present in a 2:1 to a 3:1 ratio;
- and
- b. administering to a subject in need thereof an effective dose of the composition to a subject in need thereof, wherein administration results in at least a 10% reduction in clinical symptoms and complications resulting from liver fibrosis and cirrhosis.
Dependencies are inferred from the claim text.