US 10,420,792 B2Granted

Method of treating severe asthma

AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education

InventorsAnuradha Ray, Prabir Ray, Sally Ellen Wenzel, Timothy B. Oriss

Life of this patent

Estimating the term…

Abstract

Methods are provided for treating corticosteroid-resistant asthma in a patient, comprising decreasing Interferon Regulatory Factor 5 (IRF5) activity in the patient. Antisense or RNA interference reagents and methods can be used to decrease IRF5 activity in the patient.

Claims11

Dependent claims

A method of treating corticosteroid-insensitive asthma in a patient displaying a Th1 immune profile, comprising reducing IRF5 activity to a level effective to treat one or more symptoms of asthma in a patient.

Dependencies are inferred from the claim text.

Facts

Application: 15/903,505Filed 23 Feb 2018 · us provisional application
Priority: 24 Feb 2017
Published: US 2018/0243330 A130 Aug 2018
Granted: 24 Sep 2019
Term ends: Not estimatedThe source records don’t support an estimate.

Classification6 codes

A61K 31/713
Compounds having three or more nucleosides or nucleotides: double-stranded nucleic acids or oligonucleotides
A61P 11/06
Drugs for disorders of the respiratory system: antiasthmatics
A61K 31/573
Substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone: substituted in position 21, e.g. cortisone,…
A61K 2300/00
Mixtures or combinations of active ingredients, wherein at least one active ingredient

Family

Application62/463,243Us provisional application · filed 24 Feb 2017
US 2018/0243330 A1Pre-grant publication · published 30 Aug 2018
US 10,420,792 B2This patent

From the US filing history. Foreign family members aren’t listed.

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