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US 10,420,790 B2Granted
Micellic assemblies
AssigneesUniversity of Washington, Genevant Sciences GmbH
InventorsPatrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E. E. Paschal, Charbel Diab, Priyadarsi De
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Abstract
Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instauces, micellic assemblies provided herein are pH sensitive particles.
Claims19
A micellic assembly comprising a plurality of membrane destabilizing block copolymers, the micellic assembly comprising a core and a shell,
- wherein the core comprises a plurality of core blocks of the membrane destabilizing block copolymers,
- wherein the shell comprises a plurality of shell blocks of the membrane destabilizing block copolymers,
- wherein the core block is a copolymer block that is a pH dependent membrane destabilizing hydrophobe comprising
- (i) a plurality of a first chargeable monomeric unit that is a (C2-C8)alkylacrylic acid,
- (ii) a plurality of a second chargeable monomeric unit selected from the group consisting of N,N-di(C1-C6)alkyl-amino(C1-C6)alkyl-ethacrylate, N,N-di(C1-C6)alkyl-amino(C1-C6)alkyl-methacrylate, and N,N-di(C1-C6)alkyl-amino(C1-C6)alkyl-acrylate, and
- (iii) a plurality of a hydrophobic monomeric unit selected from the group consisting of (C2-C8)alkyl-ethacrylate, (C2-C8)alkyl-methacrylate, and (C2-C8)alkyl-acrylate, and
- wherein the shell block is hydrophilic at about neutral pH.
4 more elements
Dependencies are inferred from the claim text.