Substituted nucleosides, nucleotides and analogs thereof

A method of treating a metapneumovirus infection comprising administering to a subject infected with the metapneumovirus an effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof, wherein the compound of Formula (I) has the following structure:

• wherein:
• B1A is an optionally substituted purine-base or an optionally substituted pyrimidine-base;
• R1A is selected from the group consisting of hydrogen, an optionally substituted acyl and
• the dashed line (------) is absent;
• R2A is selected from the group consisting of an unsubstituted C1-6 alkyl, a halogen substituted C1-6 alkyl, a hydroxy substituted C1-6 alkyl, an alkoxy substituted C1-6 alkyl and a sulfenyl substituted C1-6 alkyl;
• R3A is selected from the group consisting of OH and —OC(═O)R″A;
• R4A is fluoro;
• R5A is hydrogen;
• R6A and R7A are independently absent or hydrogen;
• or
• R6A is
• and R7A is absent or hydrogen;
• R12A, R13A and R14A are independently absent or hydrogen;
• R″A is an unsubstituted C1-6 alkyl;
• m is 0 or 1;
• and
• Z1A is O.