Crystal-water-free calcium dibutyryladenosine cyclophosphate crystal form and preparation method and application thereof

A method for preparing a crystal-water-free calcium dibutyryladenosine cyclophosphate crystal form, comprising:

• mixing anhydrous amorphous calcium dibutyryladenosine cyclophosphate solids with a solvent, dissolving the resulting mixture in the solvent at 25-60° C., and decolorizing by activated carbon;
• filtering the mixture to remove insoluble substances, dropwise adding an anti-solvent into a filtrate, cooling the filtrate at 0-10° C. under stirring for 1-24 h and crystallizing to produce the crystal-water-free calcium dibutyryladenosine cyclophosphate crystal form;
• wherein the crystal-water-free calcium dibutyryladenosine cyclophosphate crystal form has characteristic peaks at diffraction angles 2θ of 12.3°±0.2°, 17.60°±0.2, 21.4°±0.2°, 24.7°±0.2, 25.3°±0.2° and 27.8°±0.2° in an X-ray powder diffraction pattern taking Cu-Kα as a radiation source;
• and
• the differential scanning calorimetry map is as shown in FIG. 3.