Back to results
US 10,420,786 B2Granted
Compositions for use in cardioplegia comprising esmolol and adenosine
AssigneeAop Orphan IP AG
InventorsHazem B. Fallouh, Jonathan C. Kentish, David J. Chambers
Life of this patent
Estimating the term…
Abstract
The invention related to a composition for use in cardioplegia, said composition comprising (i) esmolol; and (ii) adenosine, wherein in use the concentration of said esmolol is in the range 0.3-1.5 mM, and wherein in use the concentration of said adenosine is in the range 0.1-1.5 mM. The invention also relates to methods of making and using such compositions.
Claims14
A method for inducing cardioplegia in a human subject, said composition comprising administering to the human subject a composition comprising.
- (i) esmolol;
- and
- (ii) adenosine;
- wherein the concentration of said esmolol is in the range 0.5 mM to 1.5 mM, wherein the concentration of said adenosine is in the range 0.25 mM to 1.5 mM, wherein the product of the concentration of esmolol and of adenosine is at least 0.15, wherein the product of the concentration is calculated by multiplying the concentration of esmolol and the concentration of adenosine expressed using millimolar concentration units.
1 more element
Dependencies are inferred from the claim text.