Back to results
US 10,420,779 B2Granted
Fusidic acid cream and method for the preparation thereof
AssigneeHyloris Pharmaceuticals SA
InventorThomas Jacobsen
Life of this patent
Estimating the term…
Abstract
The present invention relates to a composition appropriate for topical application, containing fusidic acid. The homogeneity of the fusidic acid is 90% to 110% of the suggested fusidic acid content, and the amount of air present in the cream is lower than 5 vol %. Furthermore, the present invention also relates to a method for preparing the composition. First, a placebo cream and a suspension of fusidic acid are prepared, which are subsequently mixed at a temperature above the melting point of the placebo cream.
Claims7
Method for the preparation of a topical fusidic acid composition, comprising the steps of:
- a) suspending fusidic acid having a particle size with a D90 lower than 10 μm in an aqueous phase to form a suspension;
- b) melting and mixing at least two ingredients to obtain a placebo cream;
- c) heating the placebo cream above its melting point;
- d) mixing the suspension of step a) with the placebo cream of step c) under air at an air pressure of below 25 kPa and at a lower mixing speed than employed in step b);
- wherein the mixing in step d) is realized at a temperature of minimum 5° C. above the melting point of said placebo cream, and is conducted by stirring for a time, stirring speed, and air pressure selected to achieve an amount of air present in the composition of lower than 5 vol %, and wherein polysorbate is partially added in step a) and partially in step c).
2 more elements
Dependencies are inferred from the claim text.