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US 10,420,776 B2Granted
Antibiotic compositions for nasal irrigation and methods
AssigneeRhinonase, Inc.
InventorsKambiz Yadidi, Amanda Quiroga, Jagdeep Shur, Jeffrey B. Harris
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Abstract
Provided herein are pharmaceutical formulations, nasal irrigation fluids, sachets, kits and the like comprising cephalosporin antibiotics, as well as methods of topical treatment of sinusitis and related conditions, methods of delivery of the formulations and fluids to the sinuses, methods of coating the sinuses, and methods of disruption and/or penetration of biofilms in the sinuses.
Claims14
A pharmaceutical formulation in liquid suspension form for nasal irrigation, comprising:
- i about 10%-about 50% microparticles consisting of a cephalosporin antibiotic having a diameter less than about 7 μm;
- ii. about 25%-about 90% sodium chloride in water in which the microparticles are suspended;
- iii. at least one buffering agent selected from the group consisting of citric acid monohydrate and sodium citrate dihydrate, the total amount of buffering agent amounting to about 0.1%-about 2%;
- iv. about 0.005% to about 0.5% of a surfactant selected from the group consisting of polyvinylpyrrolidone and di sodium EDTA;
- v. about 0.01% to about 1% of (a) a viscosity modifier comprising polyethylene glycol, or (b) a suspending agent comprising magnesium stearate;
- and
- vi. an amount of an acid or base sufficient to achieve a pH of between about 3 and about 8 in the liquid suspension;
- wherein a viscosity of the liquid suspension is less than 1.0 mPa·s.
5 more elements
Dependencies are inferred from the claim text.