Methods and compositions for inhibition of polymerase
AssigneeBioCryst Pharmaceuticals, Inc.
InventorsShanta Bantia, Pravin L. Kotian, Yarlagadda S. Babu
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Abstract
The present invention is directed to methods and compositions for inhibition of viral nucleic acid polymerases, such as RNA and DNA polymerases, and methods and compositions that are useful for treating viral infections in subjects. The methods comprise administering to the subject a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or hydrate thereof, or a composition comprising a compound of formula I, or a pharmaceutically acceptable salt or hydrate thereof, and a pharmaceutically acceptable carrier. The composition or method may optionally comprise one or more additional anti-viral agents.
Claims20
A method for treating a viral infection, comprising administering to a human subject in need thereof a therapeutically effective amount of a compound having the following structure:
- or a pharmaceutically acceptable salt or hydrate thereof;
- wherein the virus is selected from the group consisting of viruses of the orthomyxoviridae, bunyaviridae, flaviviridae, and filoviridae families.
A method for suppressing a viral infection, comprising administering to a human subject in need thereof a therapeutically effective amount of a compound having the following structure:
- or a pharmaceutically acceptable salt or hydrate thereof;
- wherein the virus is selected from the group consisting of viruses of the orthomyxoviridae, bunyaviridae, flaviviridae, and filoviridae families.
Dependencies are inferred from the claim text.