Allosteric inhibitors of thymidylate synthase

A method for treating cancer in a subject comprising administering an effective amount of a composition comprising one or more thymidylate synthase inhibitor,

• wherein said one or more thymidylate synthase inhibitor is a compound, selected from the group consisting of:
• and salts thereof,
• wherein
• R1, R3, R4, and R5 are independently, a hydrogen atom, methyl, C1-C5 branched or unbranched alkyl, amino, nitro, amidino, sulpho, sulphonamido, carboxy, cyano, phenyl, thienyl, pyrril, pyrazolyl, imidazolyl, isoxazyl, triazolyl, tetrazolyl, thiazolyl, oxazolyl, quinazolyl, pyridyl, pyrimidyl group, C1-C5 alkenyl, C1-C5 alkylamino, C2-C10 dialkylamino, hydroxy C1-C5 alkyl, carbonyl, C3-C7 cycloalkyl or trifluoromethyl group;
• R2 is a hydrogen atom, C1-C5 alkyl, hydroxy, amino, sulpho, sulphonamido, carboxy, or cyano group;
• X is a carbon, nitrogen, oxygen or sulphur atom at the indicated position;
• Y is a carbon, nitrogen or oxygen atom at the indicated position;
• and
• L1 and L2 are each independently C1-C5 alkylene, C2-C5 alkenylene, amidino, or ureido linker;
• and
• wherein the cancer is lung cancer, pancreatic cancer, cervical cancer, or hematopoietic cancer.