Methods of treatment associated with the granulocyte colony-stimulating factor receptor

A method for treating a cancer selected from the group consisting of a leukemia, non-small cell lung cancer, colon cancer, CNS cancer, skin cancer, ovarian cancer, renal cancer, prostate cancer, breast cancer, and myeloma, comprising administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising a compound of Formula (I), (II), Ill, or (IV) in combination with an additional therapeutic agent selected from the group consisting of a chemotherapeutic agent, bone marrow transplant, and radiation therapy, wherein the compound of Formula (I), (II), Ill, or (IV) has the structure:

• a tautomer thereof, or a pharmaceutically acceptable salt thereof,
• wherein:
• R1 is selected from hydrogen, OR6, NO2, CN, NR6R7, CO2R6, C(═O)NR6R7, SO3R6, SO2NR6R8, an optionally substituted C1-C6 alkyl, an optionally substituted C2-C6 alkenyl, an optionally substituted C2-C6 alkynyl, an optionally substituted C1-C6 heteroalkyl, an optionally substituted C3-C6 cycloalkyl, an optionally substituted C3-C6 cycloalkenyl, an optionally substituted C2-C6 heterocyclyl, an optionally substituted arylalkyl, an optionally substituted aryl, and an optionally substituted heteroaryl;
• R2 and R3 are independently selected from hydrogen, an optionally substituted C1-C6 alkyl, an optionally substituted C2-C6 alkenyl, an optionally substituted C2-C6 alkynyl, an optionally substituted C1-C6 heteroalkyl, an optionally substituted C3-C8 cycloalkyl, an optionally substituted C3-C8 cycloalkenyl, an optionally substituted C1-C6 heterocycle, an optionally substituted aryl, and an optionally substituted heteroaryl;
• R4 is selected from hydrogen, an optionally substituted C1-C6 alkyl, an optionally substituted C2-C6 alkenyl, an optionally substituted C2-C6 alkynyl, an optionally substituted C1-C6 heteroalkyl, an optionally substituted C3-C8 cycloalkyl, an optionally substituted C3-C8 cycloalkenyl, an optionally substituted C1-C6 heterocycle, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted arylalkyl, an optionally substituted arylalkenyl, an optionally substituted arylalkynyl, and an optionally substituted heteroarylalkyl;
• R5 is selected from hydrogen, halogen, NO2, CN, CF3, OR6, CO2R6, C(═O)NR6R7, SO3R6, and SO2NR6R8, an optionally substituted aryl, an optionally substituted C1-C6 alkyl, and an optionally substituted C1-C6 heteroalkyl;
• R6 is selected from hydrogen, an optionally substituted C1-C6 alkyl, a C1C6 heteroalkyl, an optionally substituted aryl, and an optionally substituted heteroaryl;
• R7 is selected from hydrogen, C(═O)R8, C(═O)NHR8, an optionally substituted C1-C6 alkyl, and an optionally substituted C1-C6 heteroalkyl;
• or —NR6R7 is an optionally substituted non-aromatic heterocycle linked through a ring nitrogen;
• R8 is selected from hydrogen, an optionally substituted C1-C6 alkyl, and an optionally substituted C1-C6 heteroalkyl;
• R9 is selected from hydrogen, an optionally substituted C1-C6 alkyl, an optionally substituted C2-C6 alkenyl, an optionally substituted C2-C6 alkynyl, an optionally substituted C1-C6 heteroalkyl, an optionally substituted C3-C8 cycloalkyl, an optionally substituted C3-C8 cycloalkenyl, an optionally substituted C1-C6 heterocycle, an optionally substituted heteroaryl, an optionally substituted arylalkyl, an optionally substituted arylalkenyl, an optionally substituted arylalkynyl, an optionally substituted heteroarylalkyl, an optionally substituted heteroarylalkenyl, and an optionally substituted heteroarylalkynyl;
• Q is selected from the group consisting of NR6, an optionally substituted C1-C6 alkyl, an optionally substituted C3-C8 cycloalkyl, an optionally substituted C1-C6 heteroalkyl, and an optionally substituted non-aromatic heterocycle;
• L1 is selected from NH and CHR2;
• W is selected from O (oxygen) and NH;
• X is N (nitrogen) or CR2;
• Y is selected from an optionally substituted C1-C6 alkyl, C2-C6 alkenyl, an optionally substituted C1-C6 heteroalkyl, an optionally substituted C1-C6 heteroalkenyl, an optionally substituted phenylalkenyl, and an optionally substituted heterocyclealkenyl;
• Z is O (oxygen) or S (sulfur);
• and
• n is 1, 2 or 3.