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US 10,420,738 B2Granted
Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction
AssigneeInstytut Biochemii I Biofizyki Pan
InventorsNorbert Odolczyk, Piotr Zielenkiewicz, Grzegorz Wieczorek, Aleksander Edelman, Danielle Tondelier, Janine Fritsch
Life of this patent
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Abstract
An exemplary embodiment relates to novel protein modulators capable of altering function of the mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction. The invention provides compositions, pharmaceutical preparations and methods of correcting the cellular alteration of a mutant CFTR protein wherein the CFTR mutation is a mutation ΔF508-CFTR, or another mutation of class II.
Claims3
A pharmaceutical composition comprising a compound represented by the following structure:
- used for manufacture of a medication for treatment of diseases associated with CFTR protein malfunction,
- or its tautomers, E and Z geometric isomers, enantiomers, diastereomers, or pharmaceutically acceptable salts thereof or complexes thereof.
Dependencies are inferred from the claim text.