Transdermal delivery system containing methylphenidate or its salts and methods thereof
AssigneeTaho Pharmaceuticals Ltd.
InventorsShen-Yung Kao, Taijung Wu, Catherine Lee
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Abstract
Disclosed herein is a transdermal delivery system comprising methylphenidate or its salt as an active ingredient. Also provided are methods of delivering a therapeutically effective amount of methylphenidate to a subject for the treatment of a disease condition. The disease condition includes a neurological condition such as Attention Deficit Disorder (ADD) and/or Attention Deficit/Hyperactivity Disorder (ADHD). Kits including the transdermal delivery system and methods of making and using the transdermal delivery system are also provided.
Claims46
A method of treating attention deficit disorder, attention deficit/hyperactivity disorder, postural orthostatic tachycardia syndrome or narcolepsy in a subject, said method comprises administering to the subject a transdermal delivery system comprising:
- (i) a silicone adhesive layer;
- and (ii) a drug-containing matrix layer comprising:
- (a) methylphenidate or its pharmaceutically acceptable salt;
- and (b) a rubber-based polymer that comprises a hydrogenated synthetic hydrocarbon tackifier, wherein the transdermal delivery system has a flux rate ranging from about 6 μg/cm2/hr-100 μg/cm2/hr between 2-18 hours after treatment is initiated and wherein the silicone adhesive layer optionally comprises a drug.
A method of treating attention deficit disorder, attention deficit/hyperactivity disorder, postural orthostatic tachycardia syndrome or narcolepsy in a subject, said method comprises administering to the subject a transdermal delivery system comprising methylphenidate that is present in an amount sufficient to achieve substantially zero order kinetics for delivery to the skin or mucosa of a patient in need thereof over a period of 18 hours, wherein the transdermal delivery system comprises a silicone adhesive layer, a drug-containing matrix layer comprising a rubber-based polymer that comprises a hydrogenated synthetic hydrocarbon tackifier.
Dependencies are inferred from the claim text.