Method for production of nanoporous multi-layer biodegradable polymeric coatings and products thereof

A method for the fabrication of biodegradable polymeric thin films comprising the following preparation steps:

• (a) selecting biodegradable polymers (BP) based on their degradation rates, monomers ratio, molecular weight, concentration and a polymer blend ratio;
• (b) spin coating the selected polymers onto cleaned inorganic or organic substrates and forming multi-layers;
• (c) preforming multi-dimensional nanopores with tailored characteristics in all of the multi-layers before administering;
• (d) providing a payload in one or more of the multi-layers and forming a delivery nanoplatform for controlled and steady release of the payload contained therein;
• (e) preparing a BP solution from said biodegradable polymers which is spin coated on the nanoplatform and then dried;
• (f) spin coating the payload comprising an organic solution containing an active drug and BP at a ratio that provides a desired active drug concentration, well dissolved in organic solvent onto the said biodegradable polymeric layers and sterilizing;
• wherein said steps are carried out in the specified order;
• and
• (g) providing the payload in at least one each of inner and outer layers of the multi-layers wherein the outer layer has a higher degradation rate than the inner layer.