Abuse resistant capsule

An immediate release parenteral abuse resistant capsule comprising a shell encapsulating a parenteral abuse resistant liquid, comprising:

• (a) an abuse-susceptible active pharmaceutical ingredient selected from the group consisting of opiates, opioids, tranquilizers, stimulants and narcotics;
• (b) at least 40 wt. % of a hydrophilic carrier selected from one or more of macrogol 400, macrogol 600, and macrogol 1500, and optionally one or more of propylene glycol, glycerol, and water, to dissolve or suspend the active pharmaceutical ingredient;
• (c) a surfactant selected from a macrogolglycerol ricinoleate, sorbitol monolaurate, macrogolglycerol hydroxystearate and caprylocaproylmacrogol-8-glycerides;
• (d) 1-10 wt. % of colloidal anhydrous silica;
• and
• (e) 0.2-0.6 wt. % of a viscosity enhancer selected from the group consisting of gums of acacia, pectin, agar, tragacanth, guar, xanthan, locust bean, tara, karaya, gellan, welan, and rhamsan;
• such that a mixture of about 250 to about 1000 milligrams of the abuse resistant liquid with 5 milliliters of water at the mixture's boiling point forms a viscous phase, wherein about 33% or less of the pharmaceutically active ingredient can be recovered from the viscous phase drawn up into a 25 millimeter needle having an inner diameter of 0.60 millimeters and wherein all weight percentages being based on a weight of the parenteral abuse resistant liquid,
• wherein the capsule releases more than 80% of the active pharmaceutical ingredient within the gastrointestinal tract within 30 minutes of administration.