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US 10,420,726 B2Granted
Abuse deterrent compositions and methods of use
AssigneeInspirion Delivery Sciences LLC
InventorsManish S. Shah, Ray J. Difalco, Stefan Aigner
Life of this patent
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Abstract
Orally administrable pharmaceutical compositions, methods of administration, and methods of making the same are provided. The pharmaceutical compositions provide abuse deterrent properties.
Claims12
A plurality of particles having a particle size distribution (D50) of about 400 μm to about 600 μm comprising:
- an active layer comprising morphine or a salt thereof, and a first polymer selected from the group consisting of:
- quaternary ammonium acrylic or methacrylic polymers, acrylic or methacrylic ester copolymers or mixtures thereof;
- and a barrier layer comprising a second polymer selected from the group consisting of:
- polyacrylates or copolymers thereof wherein the active layer and barrier layer are bonded, wherein the first polymer and second polymer are the same, and wherein the particles are configured such that the amount of drug released from the plurality of particles is no greater than 500% of the amount of drug released an intact unit dosage form comprising the same amount (w/w) as the plurality of particles, under the following identical conditions:
- 30 mL of ethanol, 25° C., agitated at 100 rpm for a period of time, wherein the period of time is selected from the group consisting of 30 minutes and 240 minutes.
2 more elements
A plurality of particles having a particle size distribution (D50) of about 400 μm to about 600 μm and comprising:
- an active layer comprising morphine or a salt thereof, and a first polymer selected from the group consisting of:
- quaternary ammonium acrylic or methacrylic polymers, acrylic or methacrylic ester copolymers or mixtures thereof;
- and a barrier layer comprising a second polymer selected from the group consisting of:
- polyacrylates or copolymers thereof wherein the active layer and barrier layer are bonded, wherein the first polymer and second polymer are the same, and wherein the particles are configured such that the rate of drug released from the plurality of particles is no greater than 500% of the rate of drug released from an intact unit dosage form comprising the same amount (w/w) as the plurality of particles, under the following identical conditions:
- 30 mL of ethanol, 25° C., agitated at 100 rpm for a period of time, wherein the period of time is selected from the group consisting of 30 minutes and 240 minutes.
2 more elements
Dependencies are inferred from the claim text.