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US 10,420,725 B2Granted
Solid dosage form of coated bisphosphonate particles
AssigneeAllergan Pharmaceuticals International Limited
InventorsPeter Persicaner, Craig Judy
Life of this patent
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Abstract
A solid dosage form comprises coated particles of bisphosphonate or a pharmaceutically acceptable analog or derivative thereof.
Claims16
A solid oral dosage form obtained by a method comprising:
- (i) combining particles of bisphosphonate with a coating solution or suspension consisting essentially of a coating and a solvent, wherein the coating contains a pharmaceutically acceptable, water soluble sugar and the amount of coating is from 10% to 70% by weight of the uncoated particles;
- (ii) drying the solution or suspension to form coated particles of bisphosphonate;
- (iii) mixing the coated particles of (ii) with excipients;
- and
- (iv) forming the coated particles and excipients into a solid dosage form, wherein the solid dosage form is formulated as a tablet and the tablet is not coated and consists essentially of:
- colloidal silicon dioxide;
- sodium stearyl fumarate;
- 20% to 40% by weight coated particles of bisphosphonate;
- and 30% to 80% by weight of one or more disintegrants selected from the group consisting of croscarmellose cellulose, crospovidone, microcrystalline cellulose, croscarmellose sodium, and sodium starch glycolate.
6 more elements
A solid oral dosage form obtained by a method comprising:
- (i) combining particles of bisphosphonate with a coating solution or suspension consisting essentially of a coating and a solvent, wherein the coating contains a pharmaceutically acceptable, water soluble sugar and the amount of coating is from 10% to 70% by weight of the uncoated particles;
- (ii) drying the solution or suspension to form coated particles of bisphosphonate;
- (iii) mixing the coated particles of (ii) with excipients;
- and
- (iv) forming the coated particles and excipients into a solid dosage form, wherein the solid dosage form is formulated as a tablet and the tablet is not coated and consists of:
- colloidal silicon dioxide;
- sodium stearyl fumarate;
- 20% to 40% by weight coated particles of bisphosphonate;
- and 30% to 80% by weight of one or more disintegrants selected from the group consisting of croscarmellose cellulose, crospovidone, microcrystalline cellulose, croscarmellose sodium, and sodium starch glycolate.
6 more elements
Dependencies are inferred from the claim text.