Shape changing drug delivery devices and methods
AssigneeIncept, LLC
InventorsPeter Jarrett, Michael J. McGrath, Timothy S. Jarrett, Rami El-Hayek, Andrew C. Vanslette, Courtney A. Rosales, Charles D. Blizzard, Amarpreet S. Sawhney
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Abstract
Drug delivery using bio-affecting drugs, particularly with shape changing drug delivery devices. Embodiments are included for depots for delivery of a therapeutic agent that change from an elongated state ex vivo to a coil in vivo where the agent is released.
Claims25
A device for drug delivery comprising a therapeutic agent disposed in a solid vehicle that comprises a first xerogel and a second xerogel, wherein the first xerogel is a rod and the second xerogel is a layer on the first xerogel, wherein the first xerogel and the second xerogel differentially swell and/or elongate in physiological solution to change the rod into a curve shape in response to a phosphate buffered saline (PBS) at 37° C., pH 7.4, wherein the solid vehicle provides a controlled release of the therapeutic agent.
Dependencies are inferred from the claim text.