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US 10,420,495 B2Granted
Enclosed desorption electrospray ionization probes and method of use thereof
AssigneePurdue Research Foundation
InventorsRobert Graham Cooks, Zheng Ouyang, Chien-hsun Chen, Ziqing Lin, Livia Schiavinato Eberlin
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Abstract
The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
Claims20
A method for analyzing a tissue section, the method comprising:
- providing a tissue section;
- directing a liquid droplet spray discharge from a desorption electrospray ionization probe onto the tissue section, wherein the liquid droplet spray discharge from the desorption electrospray ionization probe desorbs and ionizes one or more analytes from the tissue section in a manner that preserves the tissue section for further analysis;
- transferring the ions of the one or more analytes to a mass spectrometer;
- and
- determining a distribution of the one or more analytes within the tissue section, thereby analyzing the tissue section.
2 more elements
A method for analyzing a tissue section, the method comprising:
- providing a tissue section;
- directing a liquid droplet spray discharge from a desorption electrospray ionization probe onto the tissue section, wherein the liquid droplet spray discharge from the desorption electrospray ionization probe desorbs and ionizes one or more lipids from the tissue section in a manner that preserves the tissue section for further analysis;
- transferring the ions of the one or more lipids to a mass spectrometer;
- and
- determining a distribution of the one or more lipids within the tissue section, thereby analyzing the tissue section.
2 more elements
Dependencies are inferred from the claim text.