System coordinator and modular architecture for open-loop and closed-loop control of diabetes

An apparatus having a modular architecture for managing diabetes of a patient, comprising:

• a system coordinator controller device configured to receive metabolic measurement data and metabolic state estimate data of the patient and to selectively route this data to a selected number of activated controller devices selectively activated by the system coordinator controller device for particularized diabetes management of a specific patient;
• the selectively activated controller devices including:
• a daily profile controller device configured to compute a reference insulin infusion signal in response to at least a metabolic state estimate of the patient,
• a meal controller device configured to compute a recommended meal insulin infusion signal in response to data relating to intake of a meal by the patient, and
• a compensation control to target controller device configured to compute a recommended residual insulin infusion signal in response to data relating to glucose level excursions of the patient caused by non-meal occurrences;
• and
• a supervision controller device configured to receive the insulin infusion signals from the activated controller devices, receive default insulin infusion signals for non-activated controller devices, monitor these insulin infusion signals, and adjust them in accordance with a total insulin infusion amount in dependence on the number of controller devices activated in the modular system, to produce an adjusted total insulin infusion signal, wherein the supervision controller device sends the adjusted total insulin infusion signal to the patient as a suggestion, in an open loop control mode, and sends the adjusted total insulin infusion signal to an insulin infusion pump in a closed loop control mode in order for the insulin infusion pump to administer insulin based on the adjusted total insulin infusion signal, wherein the supervision controller device is distinct and external to each of the daily profile controller device, the meal controller device, and the compensation control to target controller device;
• and
• a data acquisition controller device configured to receive continuous glucose monitoring data, insulin pump data, exercise data, and meal data from external data sources, and the data acquisition controller device is configured to output data to the system coordinator controller device, such that the system coordinator controller receives the output data in addition to the received metabolic measurement data and the metabolic state estimate data.