Back to results
US 10,416,174 B1Granted
Diagnosis and prognosis for chronic fatigue syndrome
AssigneesArizona Board of Regents on behalf of Arizona State University, Whittemore Peterson Institute
InventorsStephen Albert Johnston, Phillip Stafford, Vincent Lombardi
Life of this patent
Estimating the term…
Abstract
Described herein are methods and devices for diagnosing chronic fatigue syndrome using peptide arrays, and providing a prognosis to patients.
Claims13
A method, comprising:
- a) contacting a biological sample from a patient to a peptide array, wherein the peptide array comprises peptides capable of binding to at least one antibody in the biological sample, and wherein the peptides comprise one or more peptides with SEQ ID NOS:
- 1, 3-10, 28-44, 56-97 or combinations thereof;
- b) measuring the binding of the at least one antibody to a plurality of different peptides in the peptide array to form an immunosignature;
- c) analyzing the immunosignature;
- d) associating immunosignature with chronic fatigue syndrome, thereby diagnosing the patient with chronic fatigue syndrome;
- and
- e) administering a therapeutic to treat said patient with chronic fatigue syndrome.
4 more elements
A method of treating chronic fatigue syndrome, the method comprising:
- a) receiving a biological sample from a subject;
- b) contacting the biological sample to a peptide array, wherein the peptide array comprises peptides capable of binding at least one antibody in the biological sample and wherein the peptides comprise one or more peptides with SEQ ID NOS:
- 1, 3-10, 28-44, 56-97, or combinations thereof,
- c) measuring the binding of the antibody to a plurality of the peptides to form an immunosignature;
- d) associating the immunosignature with chronic fatigue syndrome, thereby diagnosing the subject with chronic fatigue syndrome;
- and
- e) treating said subject with chronic fatigue syndrome by administering a therapeutic which targets a protein comprising one or more of the plurality of peptides bound to the antibody, thereby treating chronic fatigue syndrome.
4 more elements
A method for identifying therapeutic targets for the treatment or prevention of chronic fatigue syndrome, the method comprising:
- a) receiving a biological sample from a subject diagnosed with chronic fatigue syndrome;
- b) contacting the biological sample to a peptide array, wherein the peptide array comprises peptides capable of binding at least one antibody in the biological sample and one or more peptides from said peptide array is selected from SEQ ID NOS:
- 1, 3-10, 28-44, 56-97, or combinations thereof;
- c) measuring the binding of the antibody to a plurality of the peptides to form an immunosignature;
- d) associating the immunosignature with a prognosis of chronic fatigue syndrome;
- e) identifying one or more peptides associated with the chronic fatigue syndrome immunosignature;
- and
- f) administering an agent which targets the one or more peptides associated with the chronic fatigue syndrome immunosignature to the subject diagnosed with chronic fatigue syndrome.
5 more elements
Dependencies are inferred from the claim text.