US 10,415,881 B2 · Method and device for freeze-drying drug liposomes powder assisted by variable-frequency alternating-current electric field

Abstract

The present invention discloses a method for freeze-drying drug liposomes powder assisted by a variable-frequency alternating-current electric field, which includes the following steps: (1) preparing a drug-liposome suspension sample; (2) dehydrating the sample under a 1-10 kHz, 3-10 kV high-voltage alternating current; (3) freezing and drying the sample treated in step (2) at −20° C. to −40° C., under a 10-25 kHz, 0.2-1 kV high-voltage alternating current, until completion of the freezing process; and (4) heating and drying the sample in a vacuum until completion of sublimation and desorption, and obtaining the drug liposomes freeze-dried powder. The present invention not only greatly shortens a freezing and drying time, but also controls a size of nuclei and ice crystals, further ensuring a quality of the freeze-dried powder.

Claims14

Dependent claims

A method for freeze-drying drug liposomes powder assisted by variable-frequency alternating-current electric field is provided, wherein the method comprises the following steps:

(1) preparing a drug-liposome suspension sample;
(2) dehydrating the sample under a 1-10 kHz, 3-10 kV high-voltage alternating current;
(3) freezing and drying the sample treated in step (2) at −20° C. to −40° C., under a 10-25 kHz, 0.2-1 kV high-voltage alternating current, until completion of the freezing process;
and
(4) heating and drying the sample in a vacuum until completion of sublimation and desorption, and obtaining the drug liposomes freeze-dried powder.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

15/548,054Filed 29 Dec 2015

Priority

CN 2015 1 00946563 Mar 2015

Published

US 2018/0017324 A118 Jan 2018

Granted

17 Sep 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

F26B 7/00
Drying solid materials or objects by processes using a combination of processes
A61K 9/1277
Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant: preparation processes;…
A61K 9/19
Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles: lyophilised , i.e.…
F26B 3/34
By development of heat within the materials or objects to be dried , e.g. by fermentation or other microbiological action: by using electrical effects

Method and device for freeze-drying drug liposomes powder assisted by variable-frequency alternating-current electric field

Life of this patent

Method and device for freeze-drying drug liposomes powder assisted by variable-frequency alternating-current electric field

Life of this patent

Abstract

Claims14