Transgenic macrophages, chimeric antigen receptors, and associated methods
AssigneeThunder Biotech Inc.
InventorKim O'Neill
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Abstract
Described herein are chimeric receptors. Chimeric receptors comprise a cytoplasmic domain; a transmembrane domain; and an extracellular domain. In embodiments, the cytoplasmic domain comprises a cytoplasmic portion of a receptor that when activated polarizes a macrophage. In further embodiments, a wild-type protein comprising the cytoplasmic portion does not comprise the extracellular domain of the chimeric receptor. In embodiments, the binding of a ligand to the extracellular domain of the chimeric receptor activates the intracellular portion of the chimeric receptor. Activation of the intracellular portion of the chimeric receptor may polarize the macrophage into an M1 or M2 macrophage.
Claims17
A chimeric receptor, the chimeric receptor comprising
- a cytoplasmic domain;
- a transmembrane domain;
- and
- an extracellular domain;
- wherein the cytoplasmic domain comprises a cytoplasmic portion of a receptor that when activated polarizes a macrophage to an M2 macrophage;
- and
- wherein a wild-type protein comprising the cytoplasmic portion does not comprise the extracellular domain.
A nucleic acid comprising a polynucleotide encoding a chimeric receptor, the encoded chimeric receptor, when translated, comprising:
- a cytoplasmic domain;
- a transmembrane domain;
- and
- an extracellular domain;
- wherein the cytoplasmic domain comprises a cytoplasmic portion of a receptor that when activated polarizes a macrophage to an M2 macrophage;
- and
- wherein a wild-type protein comprising the cytoplasmic portion does not comprise the extracellular domain.
Dependencies are inferred from the claim text.