Method and intermediate for preparing tulathromycin
AssigneeZhejiang Hisun Pharmaceutical Co., Ltd.
InventorsMingxing Yin, Dongdong Wu, Weijiang Wen
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Abstract
A method and an intermediate for preparing a tulathromycin. The method includes the following step: in an organic solvent, subjecting a compound represented by formula (II) and an n-propylamine to a ring-opening addition shown below to obtain a tulathromycin represented by formula (I), wherein the organic solvent is a 1,2-propandiol. Tulathromycin obtained using the method has a high purity, with an HPLC purity being 95% and above, and up to 99% and above, satisfying a required purity for preparing a tulathromycin as a pharmaceutical formulation. The method has a high yield, is simple to operate, and is more suitable for industrial production.
Claims20
A method for preparing tulathromycin represented by formula I, comprising the following steps:
- subjecting a compound represented by formula II and n-propylamine to ring-opening addition reaction shown below in an organic solvent to produce tulathromycin represented by formula I;
- wherein the organic solvent is 1,2-propandiol;
A compound represented by formula IIIa1:
A method for purifying tulathromycin represented by formula I, comprising the following steps:
- mixing a crude tulathromycin represented by formula I with a solvent A, adding an anti-solvent, and crystallizing to obtain a product of tulathromycin represented by formula I;
- wherein the purity of the crude tulathromycin represented by formula I measured by HPLC is more than 65%;
- the solvent A is a mixed solvent of acetone and a C1-3 alcohol;
- and the anti-solvent is water or a mixed solvent of water and acetone;
Dependencies are inferred from the claim text.