Phenol derivatives to treat cancer
AssigneeFundacióN Medina. Centro De Excelencia En InvestigacióN De Medicamentos Innovadores En AndalucíA
InventorsNuria De Pedro Montejo, Victor Gonzalez Menendez, Gloria Crespo Sueiro, Ignacio Perez-Victoria Moreno De Barreda, Bastien Cautain, Maria Francisca Vicente Perez, Jose Fernando Reyes Benitez, Olga Genilloud Rodriguez, Carmen Grinan Lison, Juan Antonio Marchal Corrales
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Abstract
The present invention relates to compounds of general formula (I) wherein R1-R8 take various meanings, pharmaceutical compositions containing them and their use in medicine, particularly for the treatment and/or prophylaxis of cancer.
Claims21
A compound of general formula (I) or a pharmaceutically acceptable salt, stereoisomer, or solvate thereof
- wherein:
- A represents ═O or OH;
- R1 is hydrogen or a hydroxyl protecting group and R2 is selected from the group consisting of:
- or R1 and R2 together form a ring selected from the group consisting of:
- R3 is hydrogen or a hydroxyl protecting group;
- R4 is methyl;
- R5 is hydrogen or halogen;
- R6 is hydrogen or a hydroxyl protecting group and R7 is CHO or CH2(OH);
- or R6 and R7 together form a single bond;
- R8 is hydrogen or a hydroxyl protecting group;
- R11, R12, R13, R14 and R15 independently represent hydrogen or a hydroxyl protecting group;
- with the proviso that the compound of general formula (I) is not 2,3′,5′,6-tetrahydroxy-2′-formyl-6′-(3-methyl-2-butenyl)-4-methyl-benzophenone.
A pharmaceutical composition comprising an effective amount of at least one compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer or solvate thereof
- wherein:
- A represents ═O or OH;
- R1 is hydrogen or a hydroxyl protecting group and R2 is selected from the group consisting of:
- or R1 and R2 together form a ring selected from the group consisting of:
- R3 is hydrogen or a hydroxyl protecting group;
- R4 is methyl;
- R5 is hydrogen or halogen;
- R6 is hydrogen or a hydroxyl protecting group and R7 is CHO or CH2(OH);
- or R6 and R7 together form a single bond;
- R8 is hydrogen or a hydroxyl protecting group;
- R11, R12, R13, R14 and R15 independently represent hydrogen or a hydroxyl protecting group;
- and a pharmaceutically acceptable excipient;
- said effective amount being effective for treatment of cancer;
- with the proviso that the compound of formula (I) is not 2,3′,5′,6-tetrahydroxy-2′-formyl-6′-(3-methyl-2-butenyl)-4-methyl-benzophenone.
Dependencies are inferred from the claim text.