Back to results
US 10,414,732 B2Granted
Polymorphic compounds and uses thereof
AssigneeAldeyra Therapeutics, Inc.
InventorsAmanda Buist, Eden Fucci, Stephen G. Machatha, Osama Suleiman, Kate Wittering
Life of this patent
Estimating the term…
Abstract
The present invention provides freebase and salt forms, and compositions and methods thereof, useful for treating various conditions, in which aldehyde toxicity is implicated in the pathogenesis, by the administration of small molecule therapeutics acting as a scavenger for toxic aldehydes.
Claims15
A solid form of compound 1:
- having one or more peaks in its XRPD selected from those at about 9.3, about 16.9, and about 26.4 degrees 2-theta;
- or having one or more peaks in its XRPD selected from those at about 9.6, about 19.1, and about 28.8 degrees 2-theta.
A compound selected from:
- Compound A:
- of Form A or B, wherein Form A has one or more peaks in its XRPD selected from those at about 5.4, about 10.8, and about 16.6 degrees 2-theta and Form B has one or more peaks in its XRPD selected from those at about 11.6, about 23.3, and about 35.3 degrees 2-theta;
- Compound 2:
- of Form A or B, wherein Form A has one or more peaks in its XRPD selected from those at about 8.4, about 14.0, and about 25.4 degrees 2-theta and Form B has one or more peaks in its XRPD selected from those at about 8.4, about 26.8, and about 29.3 degrees 2-theta;
- Compound 3:
- of Form A, wherein Form A has one or more peaks in its XRPD selected from those at about 17.2, about 23.8, and about 25.5 degrees 2-theta;
- Compound 4:
- of Form A, wherein Form A has one or more peaks in its XRPD selected from those at about 13.4, about 17.0, and about 25.9 degrees 2-theta;
- Compound 5:
- of Form A, wherein Form A has one or more peaks in its XRPD selected from those at about 17.0, about 22.6, and about 26.1 degrees 2-theta;
- Compound 6:
- of Form A, wherein Form A has one or more peaks in its XRPD selected from those at about 16.9, about 19.8, and about 25.3 degrees 2-theta;
- Compound 7:
- of Form A, wherein Form A has one or more peaks in its XRPD selected from those at about 16.8, about 24.3, and about 27.8 degrees 2-theta;
- Compound 8:
- of Form A, wherein Form A has one or more peaks in its XRPD selected from those at about 7.1, about 17.2, and about 18.4 degrees 2-theta;
- or
- Compound 9:
- of Form A, wherein Form A has one or more peaks in its XRPD selected from those at about 7.2, about 8.1, and about 16.1 degrees 2-theta.
16 more elements
Dependencies are inferred from the claim text.