Dezocine analogue

A compound represented by formula (I), (II) or (III), or a pharmaceutically acceptable salt or tautomer thereof,

• wherein,
• each of X1, X2, X3 is independently single bond, CH2, C(RR), NH, N(R), O, or S;
• R12 is F, Cl, Br, I, CN, OH, or NH2, or R12 is selected from the group consisting of C1-6 alkyl or heteroalkyl, 3-7 membered cycloalkyl or heterocycloalkyl, and 5-7 membered aryl or heteroaryl, each of which is optionally substituted by 1, 2, or 3 R;
• each of R22 and R32 is independently F, Cl, Br, I, CN, OH, or NH2, or each of R22 and R32 is independently selected from the group consisting of C1-6 alkyl or heteroalkyl, 3-7 membered cycloalkyl or heterocycloalkyl, and 5-7 membered aryl or heteroaryl, each of which is optionally substituted by 1, 2, or 3 R;
• n is 1, 2, or 3;
• each of R11, R21 and R31 is independently selected from the group consisting of C1-6 alkyl and C1-6 heteroalkyl, each of which is optionally substituted by 1, 2, or 3 R;
• R23 is selected from the group consisting of C1-12 alkyl, C1-12 heteroalkyl, C3-7 cycloalkyl, and 3-7 membered heterocycloalkyl, each of which is optionally substituted by 1, 2, or 3 R;
• L is selected from the group consisting of C1-12 alkyl, C1-12 heteroalkyl, C3-7 cycloalkyl, and 3-7 membered heterocycloalkyl, each of which is optionally substituted by 1, 2, or 3 R;
• said “hetero” represents O, S, or N, the number of which is 1, 2 or 3 in any of the above cases;
• said R is F, Cl, Br, I, CN, OH, NH2, C1-3 alkyl, or C1-3 heteroalkyl;
• said C1-3 alkyl or C1-3 heteroalkyl is optionally substituted by 1, 2, or 3 substituents selected from the group consisting of F, Cl, Br, I, CN, OH, and NH2;
• two geminal or ortho R optionally connect to the same atom forming 3-6 membered cycloalkyl or heterocycloalkyl.