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US 10,414,713 B2Granted
Fatty acid compound, preparation method therefor and use therefor
AssigneeShanghai Institute of Materia Medica, Chinese Academy of Sciences
InventorsFajun Nan, Jia Li, Jingya Li, Mei Zhang, Zhifu Xie, Jingtao Wang, Dongdong Guo
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Abstract
The present invention relates to a class of fatty acid compounds, a preparation method thereof and use thereof. The fatty acid compounds have the structure of the formula I, which has the ability to activate APMK and inhibit the glucose output in mouse primary hepatocytes. The fatty acid compounds can be used in preparing a medicament for the treatment of obesity or diabetes.
Claims9
A fatty acid compound of formula II, or a pharmaceutically acceptable salt thereof:
- wherein R1 and R2 are each independently H, C1˜C4 alkyl or phenyl;
- R3, R4, R5, and R6 are each independently C1˜C4 alkyl or phenyl;
- alternatively, R5 and R6 together with their adjacent carbon atoms form a C3˜C7 cycloalkyl group, or together with their adjacent carbon atom form a C3˜C7 cycloalkenyl group,
- alternatively, R3 and R4 together with their adjacent carbon atoms form a C3˜C7 cycloalkyl group, or together with their adjacent carbon atoms form a C3˜C7 cycloalkenyl group;
- m, n are each independently 1, 2, 3, 4, 5 or 6,
- the double bond is either cis or trans.
3 more elements
Dependencies are inferred from the claim text.