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AssigneeRuprecht-Karls-UniversitäT Heidelberg
InventorsVolker Cleeves, Stephan Urban, Ralf Kubitz
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The present invention relates to lipopeptide-based compounds for use in the diagnosis, prevention and/or treatment of a liver disease or condition, preferably liver involved metabolic diseases, as well as in the control or modification of the cholesterol level or cholesterol uptake and, thus, diagnosis, prevention and/or treatment of a cardiovascular disease. The present invention furthermore relates to an in vitro or in vivo assay or method for testing or measuring the NTCP-mediated transport of test compound(s). The present invention furthermore relates to a method for the diagnosis, prevention and/or treatment of a liver disease or condition, comprising administering a therapeutically effective amount of a lipopeptide-based compound to a patient. The present invention furthermore relates to a method for the diagnosis, prevention and/or treatment of a cardiovascular disease.
A method for treating a cardiovascular disease (CVD) in a patient, the method comprising administering a therapeutically effective amount of a lipopeptide to the patient,
A method for reducing taurocholate uptake in liver cells of a human, the method comprising administering to the human an effective amount of a lipopeptide comprising the sequence selected from SEQ ID NOs:
Dependencies are inferred from the claim text.