Compositions and methods for combating drug-resistant cancers
AssigneeNational Yang-Ming University
InventorsMuh-Hwa Yang, Dennis Shin-Shian Hsu
Life of this patent
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Abstract
Compositions and methods for reducing or overcoming acquired resistance to cetuximab are provided. Compositions and methods for treatment of cetuximab-resistant cancers are also provided. In addition, methods of inhibiting the growth of EGFR-expressing tumor cells that are resistant to cetuximab therapy are provided herein.
Claims18
A method of reducing or overcoming acquired resistance to cetuximab in a patient, the method comprising administering to the patient a composition comprising a peptide that comprises an amino acid sequence of QDGLYYLYCLVGYR (SEQ ID NO:
- 5) or ERVYVNISH (SEQ ID NO:
- 9) or a combination thereof.
A pharmaceutical composition comprising a combination of anti-EGFR antibody and a peptide, and wherein the peptide comprises an amino acid sequence of QDGLYYLYCLVGYR (SEQ ID NO:
- 5) or ERVYVNISH (SEQ ID NO:
- 9) or a combination thereof, and a pharmaceutically effective carrier.
A method of treating cancer wherein the cancer is resistant to cetuximab, the method comprising administering an effective amount of a pharmaceutical composition to a patient suffering therefrom, wherein the cancer is selected from the group consisting of head and neck cancer, head and neck squamous cell carcinoma (HNSCC) and colorectal cancer.
Dependencies are inferred from the claim text.