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US 10,406,201 B2Granted
Methods for administering angiotensin II
AssigneeLa Jolla Pharma, LLC
InventorsGeorge Tidmarsh, Lakhmir Chawla
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Abstract
The present disclosure relates to the use of angiotensin II, angiotensin III, or angiotensin IV in therapeutic methods for the treatment of hypotension, especially catecholamine-resistant hypotension.
Claims16
A method of treating hypotension in a human patient, comprising:
- measuring a ratio of blood concentration of angiotensin I to blood concentration of angiotensin II in the patient;
- and
- administering to the patient a composition comprising angiotensin II.
A method of treating hypotension in a human patient receiving a vasopressor and having an initial mean arterial pressure, comprising:
- measuring a ratio of angiotensin I to angiotensin II;
- administering to the patient a composition comprising angiotensin II in the patient;
- after a subsequent period of time, measuring the mean arterial pressure of the patient;
- and
- if the measured mean arterial pressure is at or above 75 mm Hg, decreasing the rate at which the vasopressor is administered to the patient.
2 more elements
A method of treating hypotension in a human patient receiving a vasopressor and having an initial mean arterial pressure, comprising:
- measuring a ratio of blood concentration of angiotensin I to blood concentration of angiotensin II in the patient;
- administering to the patient a composition comprising angiotensin II;
- after a subsequent period of time, measuring the mean arterial pressure of the patient;
- and
- if the measured mean arterial pressure is at least 10 mm Hg higher than the initial mean arterial pressure, decreasing the rate at which the vasopressor is administered to the patient.
2 more elements
Dependencies are inferred from the claim text.