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US 10,405,753 B2Granted
Pharmaceutical compositions of near IR closed chain, sulfo-cyanine dyes
AssigneeIntuitive Surgical Operations, Inc.
InventorJonathan Sorger
Life of this patent
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Abstract
Sterile and non-toxic pharmaceutical compositions of near IR, closed chain, sulfo-cyanine dyes and methods for visualizing tissue under illumination with near-infrared radiation are provided.
Claims11
A method of visualizing tissue in a patient, the method comprising the step of administering a sterile pharmaceutical composition comprising a unit dosage form of a compound having the formula:
- wherein,
- R1, R2, R3, and R4 are each independently hydrogen, C1-3 alkyl, or —CO2T;
- X is a single bond, —O—, or —S—;
- subscripts a, b, c, and d are each independently an integer from 1 to 6, and
- T is a metal ion, H, or a negative charge;
- wherein the composition is non-toxic, and wherein the unit dosage form delivers to the patient an amount sufficient to visualize tissue;
- and further comprising imaging the tissue under illumination with near-infrared radiation, and obtaining at least one image of the tissue from the patient using the composition.
4 more elements
Dependencies are inferred from the claim text.