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US 10,400,013 B2Granted
Fusion polypeptide for immuno-enhancement and method for enhancing stimulation of immune response using the same
AssigneeChao-Wei Liao
InventorsChao-Wei Liao, Ting-Kai Liao
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Abstract
A fusion polypeptide is disclosed, which includes: (a) a mucosa targeting polypeptide; (b) a translocating peptide for translocation; and (c) a antigenic epitope. In addition, a method for enhancing a stimulation of an immune response using the aforementioned fusion polypeptide is also disclosed.
Claims33
A fusion polypeptide, comprising:
- (a) a mucosa targeting polypeptide, wherein the mucosa targeting polypeptide comprises an amino acid sequence selected from SEQ ID NOs:
- 1 to 4;
- (b) a first translocating peptide for translocation;
- and
- (c) a first epitope-containing peptide.
2 more elements
A method for enhancing a stimulation of an immune response, comprising:
- administering a composition to a subject in need, wherein the composition comprises a vaccine and a fusion polypeptide, and the fusion polypeptide comprises:
- (a) a mucosa targeting polypeptide, wherein the mucosa targeting polypeptide comprises an amino acid sequence selected from SEQ ID NOs:
- 1 to 4;
- (b) a first translocating peptide for translocation;
- and
- (c) a first epitope-containing peptide.
3 more elements
A fusion polypeptide, comprising:
- (b) a first translocating peptide for translocation;
- and
- (c) a first antigenic epitope selected from SEQ ID NOs:
- 10 and 12.
1 more element
A method for treating or preventing HPV, comprising:
- administering a composition to a subject in need, wherein the composition comprises an anti-HPV vaccine and a fusion polypeptide, and the fusion polypeptide comprises:
- (b) a first translocating peptide for translocation;
- and
- (c) a first antigenic epitope selected from SEQ ID NOs:
- 10 and 12.
2 more elements
Dependencies are inferred from the claim text.