Use of alpha-hydroxy carbonyl compounds as reducing agents
AssigneeMorvus Technology Limited
InventorRichard J. Knox
Life of this patent
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Abstract
There is provided the use as reducing agents of alpha-hydroxycarbonyl compounds capable of forming cyclic dimers. There is also provided corresponding methods of reducing reducible compounds, particularly reduction-activated prodrugs. Examples of the alpha-hydroxycarbonyl compounds used are dihydroxyacetone, glycolaldehyde, glyceraldehyde, erythrose, xylulose, erythrulose or 3-hydroxy-2-butanone.
Claims8
A topical pharmaceutical composition suitable for use in medicine comprising 5-(aziridine-1-yl)-4-hydroxylamino-2-nitrobenzamide and a topically-acceptable adjuvant, a topically-acceptable diluent or a topically-acceptable carrier.
A dry powder aerosol composition comprising 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide.
A device that is:
- (a) a mechanical sprayer having a reservoir loaded with a solution or suspension comprising 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide and a pharmaceutically-acceptable adjuvant, diluent or carrier;
- or
- (b) an aerosol device comprising a solution or suspension comprising one or more propellant gases and 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide and a pharmaceutically-acceptable adjuvant, diluent or carrier.
Dependencies are inferred from the claim text.