Processes for preparing oxathiazin-like compounds
AssigneeGeistlich Pharma AG
InventorRolf W. Pfirrmann
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Abstract
Oxathiazin-like compounds, processes for making new oxathiazin-like compounds, compounds useful for making oxathiazin-like compounds, and their uses are disclosed. Processes of treating patients suffering from cancers, bacterial infections, fungal infections and/or viral infections by administering oxathiazin-like compounds are also disclosed. These compounds were found to have significantly longer half-life compared to taurolidine and taurultam.
Claims21
A process for preparing compound 2245, compound 2250, and/or compound 2255, comprising reacting compound 2244 as follows:
- reacting compound 2245 as follows:
- and/or reacting compound 2245 as follows:
A method of treating a subject having pancreatic cancer comprising administering compound 2250
- and/or taurolidine in combination with gemcitabine to the subject.
A process for preparing compounds 2245 and 2250 comprising reacting compound 2244 as follows:
A process for preparing compound 2250 comprising reacting compound 2245 as follows:
A process for preparing compounds 2250 and 2255 comprising reacting compound 2245 as follows:
A process for preparing compound 2244 by reacting compound 2264 as follows:
A process for preparing compound 2264 by reacting compound 2261 as follows:
A process of preparing compound 2250 using compound 2244 according to the following reaction:
A process of preparing compound 2250 using compound 2244 according to the following reaction:
Dependencies are inferred from the claim text.