Carbon dioxide liquid phase forming using high volume head displacement

An actuator of a pumping system used in a chromatography system, the actuator comprising:

• a fluidic chamber that is an intake chamber of the actuator of a pump in the pumping system receiving carbon dioxide at or above room temperature;
• and
• a movable plunger extending into and closely received by the intake chamber, the movable plunger having a diameter and stroke length adapted to compress a volume of the carbon dioxide received by the intake chamber at a given pressure to within about 10% or more of the density of the carbon dioxide in liquid phase, wherein the chromatography system includes the pump;
• and
• wherein the plunger pumps a metered amount of the compressed carbon dioxide from the pump directly to a sample manager of the chromatography system.

A pumping system used in a chromatography system, the pumping system comprising:

• an actuator having a fluidic chamber that is an intake chamber of a pump that receives carbon dioxide at or above room temperature and a movable plunger extending into and closely received by the intake chamber, the plunger having a diameter and stroke length adapted to compress a volume of the carbon dioxide received by the intake chamber at a given pressure to within about 10% or more of the density of the carbon dioxide in liquid phase;
• wherein the chromatography system includes the pump;
• and
• wherein the plunger pumps a metered amount of the compressed carbon dioxide from the pump to transport the compressed carbon dioxide directly to a sample manager of the chromatography system.