Synthesis process of precursors of derivatives of beta-lactam nuclei and precursors and derivatives thereof
OwnerPaolo Bonomiinventor
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Abstract
A synthesis process of precursors of derivatives of beta-lactam compounds, said beta-lactam compounds being selected from 6-aminopenicillanic acid and 7-aminocephalosporanic acid, preferably 6-aminopenicillanic acid, comprising the following steps: a) protection of the amine group of the beta-lactam compound, selected from 6-aminopenicillanic acid and 7-aminocephalosporanic acid, preferably 6-aminopenicillanic acid, through the formation of a carbamate by reaction with a dicarbonate; b) esterification of the carboxyl group in position 2 of the beta-lactam compound obtained in step a) by reaction with propargyl alcohol.
Claims16
A synthesis process of triazole derivatives of β-lactam compounds, comprising the following steps:
- a) protection of the amine group of the β-lactam compound, selected from a group consisting of 6-aminopenicillanic acid and 7-aminocephalosporanic acid through the formation of a carbamate by reaction with a dicarbonate;
- b) esterification of the carboxyl group in position 2 of the β-lactam compound obtained in step a) by reaction with propargyl alcohol to obtain a precursor;
- and
- c) cycloaddition reaction between the precursor obtained in step b) and an organic azide, resulting in the formation of a corresponding triazole derivative of the β-lactam compound.
Dependencies are inferred from the claim text.