Methods of using select Schiff base compounds for chemical agent detoxification
AssigneeThe United States of America as represented by the Secretary of the Air Force
InventorsJeffery Ray Owens, Wallace Bruce Salter, Katherine Moss Simpson
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Abstract
A method of using select Schiff base compounds for chemical agent detoxification. The method including applying a compound to the contaminated substrate. The compound includes an imine having at least one Schiff base nitrogen and an alkyl substituent or an aryl substituent having an electron acceptor. The at least one Schiff base nitrogen is spaced away from the electron acceptor by a distance ranging from about 200 pm to about 1000 pm. The substrate and the compound are dried. The at least one Schiff base nitrogen of the compound promotes a nucleophilic attack on an electrophilic site of the toxic chemical agent.
Claims14
A method of detoxifying a substrate contaminated with a toxic chemical agent, the method comprising:
- applying a composition to the contaminated substrate, the composition comprising 8-hydroxyquinoline or 1,2-benzisothiazol-3(2H)-one;
- and
- drying the substrate with the composition.
The method of 1, wherein the toxic chemical agent is a nerve chemical warfare agent or a blister chemical warfare agent.
A method of preparing a detoxifying substrate, the method comprising:
- selecting a first composition based on a first expected toxic chemical agent exposure, the first composition comprising 8-hydroxyquinoline or 1,2-benzisothiazol-3(2H)-one;
- applying a quantity of the first selected composition to the substrate;
- and
- optionally drying the substrate.
A method of pretreating a substrate to resist toxic chemical agent contamination, the method comprising:
- applying a composition to the substrate, the composition comprising 8-hydroxyquinoline or 1,2-benzisothiazol-3(2H)-one;
- drying the substrate with the composition;
- and
- exposing the pretreated substrate to a toxic chemical agent.
The method of 10, wherein the toxic chemical agent is a nerve chemical warfare agent or a blister chemical warfare agent.
Dependencies are inferred from the claim text.