US 10,381,211 B2 · Method and system of atmospheric pressure megavolt electrostatic field ionization desorption (APME-FID)

Abstract

On field ionization under ambient conditions is described and applied on both ionization and desorption of various chemicals and biochemical present on the surface of materials in solid, liquid or gas states. The Atmospheric Pressure Megavolt Electrostatic Field Ionization Desorption (APME-FID) method generates ions directly from the surface of samples connected to a high electrical voltage at megavolt conditions. Megavolt electrostatic potential is generated and gradually accumulated directly on the sample surface by a Van de Graaff generator without causing damage to the sample. Therefore, when coupled with mass spectrometric system, the APME-FID-MS method enables direct detection of analytes on the surface of samples in different sizes and diverse types.

Claims11

Dependent claims

A system for analyzing samples, comprising:

a megavolt electrostatic generator configured to generate megavolt electrostatic potential,
an electrically conductive material operatively coupled to the megavolt electrostatic generator that directs the megavolt electrostatic potential to a sample comprising a plurality of analyte molecules, the sample being in a solid state,
the plurality of analyte molecules ionized from the sample by the megavolt electrostatic potential to form a plurality of analyte ions,
the plurality of analyte ions desorbed from the sample,
an inlet positioned to facilitate a transfer of the plurality of analyte ions desorbed from the sample to an analyzer,
the system configured to analyze the sample without the use of an assisting reagent, a laser desorption technique, or a combination thereof.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

15/283,522Filed 10 Apr 2015 · us provisional application

Priority

11 Apr 2014

Published

US 2017/0084442 A123 Mar 2017

Granted

13 Aug 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

H01J 49/168
Using surface ionisation, e.g. field-, thermionic- or photo-emission: field ionisation, e.g. corona discharge
H01J 49/0422
Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or…: for…
H01J 49/0431
Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or…: for…
H01J 49/0459
Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or…: for…

Method and system of atmospheric pressure megavolt electrostatic field ionization desorption (APME-FID)

Life of this patent

Method and system of atmospheric pressure megavolt electrostatic field ionization desorption (APME-FID)

Life of this patent

Abstract

Claims11