Antibodies to paliperidone and use thereof
AssigneeJanssen Pharmaceutica NV
InventorsEric Hryhorenko, Banumathi Sankaran, Thomas R. DeCory, Theresa Tubbs, Linda Colt, Maarten Vliegen, Pieter Rik Haspeslagh
Life of this patent
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Abstract
Disclosed is an antibody which binds to paliperidone, which can be used to detect paliperidone in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of paliperidone, including multiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone/paliperidone in a single lateral flow assay device.
Claims11
An isolated antibody or a binding fragment thereof, which specifically binds to paliperidone comprising a light chain variable region comprising CDR1, CDR2 and CDR3 of SEQ ID NO:3, and a heavy chain variable region comprising CDR1, CDR2 and CDR3 of SEQ ID NO:4, wherein the light chain CDR1 sequence comprises amino acid residues 44 to 60 of SEQ ID NO:3;
- the light chain CDR2 sequence comprises amino acid residues 76 to 82 of SEQ ID NO:3;
- the light chain CDR3 sequence comprises amino acid residues 115 to 123 of SEQ ID NO:3;
- the heavy chain CDR1 sequence comprises amino acid residues 45 to 54 of SEQ ID NO:4;
- the heavy chain CDR2 sequence comprises amino acid residues 69 to 85 of SEQ ID NO:4;
- and the heavy chain CDR3 sequence comprises amino acid residues 118 to 122 of SEQ ID NO:4.
Dependencies are inferred from the claim text.