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US 10,379,127 B2Granted
Marker of cell death
AssigneeWelcome Receptor Antibodies Pty Ltd
InventorsPeter John Wookey, Sebastian George Barton Furness
Life of this patent
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Abstract
The present invention relates to methods for detecting cell death in a cell or a sample comprising cells, or in cultured cells in vitro by detecting the level of calcitonin receptor. The present invention also relates to methods of imaging cell death in a subject, compositions useful for detecting cell death in a cell or in a subject, methods of screening for modulators of cell death, and methods of staging and monitoring the progress of disease by detecting cell death.
Claims11
A method for detecting cell death in a cell, the method comprising:
- i) contacting a cell with a compound that binds calcitonin receptor, and
- ii) detecting the compound in or on the cell,
- wherein the level of the compound in or on the cell is indicative of cell death, and wherein the compound that binds calcitonin receptor is an antibody conjugated to a detectable label, wherein the antibody binds an epitope within an amino acid sequence provided as any one of SEQ ID NOs:6 to 12.
Dependencies are inferred from the claim text.