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US 10,379,123 B2Granted
Peptide, antibody thereof, and method of assessing risk of oral cancer by using peptide
AssigneesTungchai University, Taichung Veterans General Hospital
InventorsFeng-Di Lung, Ye-song Gu, Bor-rung Ou, Chi-Sheng Cheng, Man-Yee Chan
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Abstract
The present application discloses a THLW peptide, an amino acid sequence of which is represented by SEQ ID No. 1. The THLW peptide can be used as a biomarker for diseases, such as oral cancer and cervical cancer, etc., relating to infection of human papilloma virus (HPV), therefore, THLW peptide as an antigen or an anti-THLW peptide antibody prepared can be used to detect the risk of developing cancer for sample providers.
Claims4
A method of detecting risk of developing oral cancer, the method comprising the following steps:
- a) preparing an anti-THLW antibody, wherein an amino acid of a THLW peptide is represented by SEQ ID No. 1, wherein the anti-THLW antibody recognizes an epitope comprised in SEQ ID NO:
- 1;
- and
- b) allowing the antibody of step a) to react with a specimen;
- and indicating that the specimen contains human papilloma virus and the specimen provider has a high risk of developing the oral cancer when a variation of a response unit (RU) between the specimen and the antibody is higher than a first preset value, or indicating that the specimen provider has a low risk of developing the oral cancer when the variation of the response unit between the specimen and the antibody is higher than a second preset value,
- wherein the RU is equivalent to values obtained for measuring antigen-antibody interaction in immune assays,
- wherein the specimen is saliva.
4 more elements
Dependencies are inferred from the claim text.