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US 10,379,078 B2Granted
Biosensor and method for analyzing analyte concentration in a liquid sample
AssigneeNational Tsing Hua University
InventorsYu-Lin Wang, Jen-Inn Chyi, Chia-Ho Chu, Indu Sarangadharan
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Abstract
A biosensor includes a transistor and a reactive electrode. The transistor has a source, a drain and a gate surface disposed therebetween. The reactive electrode is spaced apart from the gate surface of the transistor, has a receptor immobilized thereon for specific binding with an analyte in a liquid sample, and is configured to contact the liquid sample together with the gate surface of the transistor.
Claims8
A method for analyzing concentration of an analyte in a liquid sample, comprising:
- applying the liquid sample to a biosensor, wherein the biosensor includes a transistor that has a drain, a source and a gate surface disposed between the drain and the source, and a reactive electrode spaced apart from the gate surface of the transistor, the reactive electrode having a receptor immobilized thereon for specific binding with the analyte in the liquid sample and being configured to, together with the gate surface of the transistor, contact the liquid sample;
- applying a voltage pulse between the reactive electrode and the source of the transistor, the voltage pulse having a pulse width;
- monitoring a response current, which is produced in response to the voltage pulse, within the pulse width from the biosensor;
- performing arithmetic computational processing to divide entries of the response current by a maximum value of the response current;
- performing integration computational processing on results of the arithmetic computational processing with respect to at least a certain period in the pulse width to obtain time constant;
- and
- analyzing the time constant that is correlated to the concentration of the analyte in the liquid sample.
4 more elements
Dependencies are inferred from the claim text.