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US 10,379,056 B2Granted
Diagnosis of cancer
AssigneeTodos Medical Ltd.
InventorsJoseph Kapelushnik, Shaul Mordechai, Ilana Nathan, Udi Zelig, Rami Zigdon
Life of this patent
Estimating the term…
Abstract
A method is provided including obtaining an infrared (IR) spectrum of a blood plasma sample by analyzing the blood plasma sample by infrared spectroscopy, and based on the infrared spectrum, generating an output indicative of the presence of a solid tumor or a pre-malignant condition. Other applications are also described.
Claims15
A method for indicating whether a subject has a solid tumor of a lung of the subject, the method comprising:
- isolating, using a gradient, a blood plasma sample from a peripheral blood sample taken from the subject;
- drying, using a dryer, the blood plasma sample of the subject;
- measuring an infrared (IR) spectrum of the dried blood plasma sample of the subject by analyzing the dried blood plasma sample by infrared spectroscopy, and assessing a characteristic of the dried blood plasma sample at at least one wavenumber selected from the group consisting of:
- 793±4 cm−1, 963±4 cm−1, 997±4 cm−1, 1008±4 cm−1, 1030±4 cm−1, 1048±4 cm−1, 1159±4 cm−1, 1255±4 cm−1, 1555±4 cm−1, and 1681±4 cm−1;
- using a data processor, comparing at the at least one wavenumber (a) the infrared spectrum of the dried blood plasma sample of the subject to (b) an infrared spectrum obtained from a dried blood plasma sample from a person without a solid tumor, to detect a difference between the infrared spectrum of the dried blood plasma sample of the subject and the infrared spectrum obtained from the dried blood plasma sample from the person without a solid tumor;
- and
- based on the comparing, generating an output indicative of the presence of a solid tumor of the lung of the subject.
4 more elements
A system for indicating whether a subject has a solid tumor of a lung of the subject, the system comprising:
- a gradient configured to isolate a blood plasma sample from a peripheral blood sample of the subject;
- a dryer configured to dry the blood plasma sample;
- a data processor, configured (i) to analyze an infrared (IR) spectrum of the dried blood plasma sample of the subject by assessing a characteristic of the dried blood plasma sample at at least one wavenumber selected from the group consisting of:
- 793±4 cm−1, 963±4 cm−1, 997±4 cm−1, 1008±4 cm−1, 1030±4 cm−1, 1048±4 cm−1, 1159±4 cm−1, 1255±4 cm−1, 1555±4 cm−1, and 1681±4 cm−1, and (ii) to compare at the at least one wavenumber (a) the infrared spectrum of the dried blood plasma sample of the subject to (b) an infrared spectrum obtained from a dried blood plasma sample from a person without a solid tumor, to detect a difference between the infrared spectrum of the dried blood plasma sample of the subject and the infrared spectrum obtained from the dried blood plasma sample from the person without a solid tumor;
- and
- an output unit, configured to generate an output indicative of the presence of a solid tumor of the lung of the subject, based on the comparing.
3 more elements
A computer program product for administering processing of a body of data, the
- product comprising a computer-readable medium having program instructions embodied therein, which instructions, when read by a computer, cause the computer to:
- measure an infrared (IR) spectrum of a dried blood plasma sample by analyzing the dried blood plasma sample by infrared spectroscopy;
- assess a characteristic of the dried blood plasma sample at at least one wavenumber selected from the group consisting of:
- 793±4 cm−1, 963±4 cm−1, 997±4 cm−1, 1008±4 cm−1, 1030±4 cm−1, 1048±4 cm−1, 1159±4 cm−1, 1255±4 cm−1, 1555±4 cm−1, and 1681±4 cm−1;
- compare at the at least one wavenumber (a) the infrared spectrum of the dried blood plasma sample of the subject to (b) an infrared spectrum obtained from a dried blood plasma sample from a person without a solid tumor, to detect a difference between the infrared spectrum of the dried blood plasma sample of the subject and the infrared spectrum obtained from the dried blood plasma sample from the person without a solid tumor;
- and
- based on the comparison, generate an output indicative of the presence of a solid tumor of a lung of the subject.
4 more elements
Dependencies are inferred from the claim text.