Paper-based surface-enhanced raman scattering substrate, and preparation method therefor
AssigneeUniversity-Industry Cooperation Group of Kyung Hee University
InventorsSam Jin Choi, Wan Sun Kim, Jae-Ho Shin, Hun Kuk Park
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Abstract
The present invention relates to: a paper-based surface-enhanced Raman scattering (SERS) substrate comprising metal nanoparticles, which are uniformly distributed and adsorbed on a designed pattern and have a diameter of 1 nm to 100 nm; a point-of-care (POC) diagnostic kit, comprising the paper-based SERS substrate; and a method for preparing the paper-based SERS substrate.
Claims15
A method for preparing a paper-based surface-enhanced Raman Scattering (SERS) substrate which comprises metal nanoparticles having a diameter of 1 nm to 100 nm uniformly distributed and adsorbed in a designed pattern, the method comprising:
- step (1) of immersing a paper substrate in a precursor solution of a 1st metal for the adsorption of precursors of the 1st metal on the substrate;
- step (2) of immersing the paper substrate, on which the precursors of the 1st metal are adsorbed, in a 1st buffer for washing;
- step (3) of immersing the washed paper substrate in a solution of a Pt reducing agent to form nanoparticles of the Pt metal;
- and
- step (4) of immersing the nanoparticles of the 1st metal grown on the paper substrate in a 1′th buffer for washing.
A method for preparing a paper-based surface-enhanced Raman Scattering (SERS) substrate which comprises metal nanoparticles having a diameter of 1 nm to 100 nm uniformly distributed in a designed pattern and further comprises carboxymethylcellulose, the method comprising:
- step (1) of preparing a solution of metal nanoparticles by mixing metal nanoparticles and an aqueous solution of carboxymethylcellulose, wherein the solution of metal nanoparticles has a viscosity of 500 cP to 10,000 cP;
- step (2) of preparing a paper substrate on which a desired pattern is formed;
- and
- step (3) of coating the solution of metal nanoparticles of step (1), on the paper substrate, wherein an outwardly-directed surface tension at an interface of the pattern is inhibited.
Dependencies are inferred from the claim text.