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US 10,378,063 B2Granted
RAF1 fusions
AssigneeBlueprint Medicines Corporation
InventorsNicolas Stransky, Joseph L. Kim
Life of this patent
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Abstract
The invention provides to RAF1 gene fusions, RAF1 fusion proteins, and fragments of those genes and polypeptides. The invention further provides methods of diagnosing and treating diseases or disorders associated with RAF1 fusions, such as conditions mediated by aberrant RAF1 expression or activity, or overexpression of RAF1.
Claims6
A method for detecting in a patient an AGGF1:RAF1 fusion, said method comprising:
- a) contacting a biological sample from the patient with an oligonucleotide that hybridizes to or amplifies an AGGF1:RAF1 fusion junction of SEQ ID NO:
- 1 and
- b) detecting binding between the AGGF1:RAF1 fusion and the oligonucleotide or detecting amplification of the AGGF1:RAF1 fusion junction.
Dependencies are inferred from the claim text.