US 10,378,027 B2Granted

RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci

AssigneeThe General Hospital Corporation

InventorsJ. Keith Joung, Morgan Maeder

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Abstract

Methods and constructs for RNA-guided targeting of heterologous functional domains such as transcriptional activators to specific genomic loci.

Claims11

Dependent claims

A fusion protein comprising a catalytically inactive CRISPR associated 9 (dCas9) protein linked to a heterologous functional domain, wherein the heterologous functional domain is a Ten-Eleven Translocation (TET) protein.

Dependencies are inferred from the claim text.

Facts

Application: 14/775,869Filed 14 Mar 2014 · us provisional application
Priority: 15 Mar 2013
Published: US 2016/0010076 A114 Jan 2016
Granted: 13 Aug 2019
Term ends: Not estimatedThe source records don’t support an estimate.

Classification29 codes

C12N 15/907
Using homologous recombination: in mammalian cells
C07K 14/005
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof: from viruses
C07K 14/195
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof: from bacteria
C12N 9/0071
Oxidoreductases: acting on paired donors with incorporation of molecular oxygen

Family

Application61/799,647Us provisional application · filed 15 Mar 2013
Application61/838,178Us provisional application · filed 21 Jun 2013
Application61/838,148Us provisional application · filed 21 Jun 2013
Application61/921,007Us provisional application · filed 26 Dec 2013
US 2016/0010076 A1Pre-grant publication · published 14 Jan 2016
US 10,378,027 B2This patent

From the US filing history. Foreign family members aren’t listed.

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