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US 10,378,026 B2Granted
RNA based method to obtain stably integrated retroviral vectors
AssigneeCellectis
InventorsAndrew Scharenberg, Julianne Smith, Roman Galetto
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Abstract
The present invention relates to viral transformation method, particularly foamy virus-mediated transformation method. The present invention relates to the transfer of transgene into cells by the safe and efficient transfer of RNA encoding foamy components. The present invention has therefore therapeutic interest, especially in the field of gene therapy.
Claims11
A method comprising:
- (a) providing at least one RNA comprising:
- (i) a sequence encoding foamy virus Gag protein, (ii) a sequence encoding foamy virus Pol protein;
- (iii) a Foamy Virus genomic sequence and a transgene;
- and
- (b) introducing said RNA into a cell by electroporation, such that the transgene is integrated within the genome of the electroporated cell.
2 more elements
Dependencies are inferred from the claim text.